Scavenger receptors were first described by Michael Brown and Joseph Goldstein in 1979 based on a finding that macrophages endocytosed and degraded acetylated low density lipoprotein (LDL) at a higher rate than native LDL. Subsequent studies showed that they bound multiple ligands, ranging from bacteria, protozoa, self, and modified self targets.
There are currently eight classes of scavenger receptors, classes A-H. Many of these receptors have multiple names, leading to some inconsistencies and confusion.
A workshop was organized by the NIAID, NIH to help develop a clear definition of scavenger receptors, and a standard nomenclature based on that definition. Fifteen active members of the scavenger receptor field participated in this meeting and reached a consensus definition and a proposed nomenclature for scavenger receptors.
A paper describing the proposed nomenclature was recently published in the Journal of Immunology (The Journal of Immunology March 1, 2014 vol. 192 no. 5 1997-2006).
We would like to invite the wider scientific community to provide your comments in response to the proposed nomenclature. Please click on the gene list links below to log your comments or suggestions.
Last Updated April 29, 2014
Last Reviewed April 29, 2014